In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with
neurodegenerative diseases and the specific neurological manifestations of COVID-19 have …

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …

To increase the efficacy of radiation, iron oxide nanoparticles can be utilized for their ability
to produce reactive oxygen species (ROS). Radiation therapy promotes leakage of electrons …

Lysosomal death pathways are being explored as alternatives of overcoming cancer tumor
resistance to traditional forms of treatment. Nanotechnologies that can selectively target and …

Multidrug resistance (MDR) is a primary hindrance to curative cancer chemotherapy. In this
respect, lysosomes were suggested to play a role in intrinsic MDR by sequestering …

The ability to control the movement of nanoparticles remotely and with high precision would
have far-reaching implications in many areas of nanotechnology. We have designed a …

Glioblastoma multiforme is the most aggressive brain tumor, due to its high invasiveness
and genetic heterogeneity. Moreover, the blood–brain barrier prevents many drugs from …

Hydroxychloroquine (HCQ) is a lysosomotropic autophagy inhibitor being used in over 50
clinical trials either alone or in combination with chemotherapy. Pharmacokinetic (PK) and …

Magnetic nanostructures and nanomaterials play essential roles in modern bio medicine
and technology. Proper surface functionalization of nanoparticles (NPs) allows the selective …