Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival,
metabolism, and immunity. mTOR is usually assembled into several complexes such as …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …

Chemoresistance of cancer cells is a major problem in treating cancer. Knowledge of how
cancer cells may die or resist cancer drugs is critical to providing certain strategies to …

Autophagy, defined as a scavenging process of protein aggregates and damaged
organelles mediated by lysosomes, plays a significant role in the quality control of …

Autophagy, which is tightly regulated by a series of autophagy-related genes (ATGs), is a
vital intracellular homeostatic process through which defective proteins and organelles are …

Abstract Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles are widely reported as a pH-
sensitive drug delivery carrier with high loading capacity for tumor therapy. However, the …

Chemotherapy plays crucial roles in the clinical treatment of non-small cell lung cancer
(NSCLC). Nevertheless, acquired chemoresistance is a common and critical problem that …

Gastric carcinogenesis arises from complicated interactions among host, environmental and
bacterial factors, which cause genetic and epigenetic dysregulation of oncogenic and tumor …