Managing drug-resistant epilepsy: challenges and solutions

L Dalic, MJ Cook - Neuropsychiatric disease and treatment, 2016 - Taylor & Francis
Despite the development of new antiepileptic drugs (AEDs),~ 20%–30% of people with
epilepsy remain refractory to treatment and are said to have drug-resistant epilepsy (DRE) …

Depression and anxiety in people with epilepsy

OY Kwon, SP Park - Journal of clinical neurology, 2014 - synapse.koreamed.org
Many recent epidemiological studies have found the prevalence of depression and anxiety
to be higher in people with epilepsy (PWE) than in people without epilepsy. Furthermore …

Anxiety and depressive disorders in people with epilepsy: a meta‐analysis

AJ Scott, L Sharpe, C Hunt, M Gandy - Epilepsia, 2017 - Wiley Online Library
Objective Comorbid anxiety and depressive disorders in people with epilepsy (PWE) are
highly prevalent and associated with various adverse outcomes. However, the prevalence of …

Validation of the Generalized Anxiety Disorder-7 (GAD-7) among Chinese people with epilepsy

X Tong, D An, A McGonigal, SP Park, D Zhou - Epilepsy research, 2016 - Elsevier
Abstract Objective To validate the Chinese version of the Generalized Anxiety Disorder-7
(GAD-7) in Chinese people with epilepsy (PWE). Methods A consecutive cohort of PWE from …

Predictors of health‐related quality of life and costs in adults with epilepsy: a systematic review

RS Taylor, JW Sander, RJ Taylor, GA Baker - Epilepsia, 2011 - Wiley Online Library
Purpose: Given the high burden of epilepsy on both health‐related quality of life (HRQoL)
and costs, identification of factors that are predictive of either reduced HRQoL or increased …

Rapid detection of major depression in epilepsy: a multicentre study

FG Gilliam, JJ Barry, BP Hermann, KJ Meador… - The Lancet …, 2006 - thelancet.com
Background Depression is a common comorbid disorder in epilepsy but is not routinely
assessed in neurology clinics. We aimed to create a rapid yet accurate screening instrument …

Clinical management of drug resistant epilepsy: a review on current strategies

D Guery, S Rheims - Neuropsychiatric Disease and Treatment, 2021 - Taylor & Francis
Drug resistant epilepsy (DRE) is defined as the persistence of seizures despite at least two
syndrome-adapted antiseizure drugs (ASD) used at efficacious daily dose. Despite the …

Anxiety in patients with epilepsy: systematic review and suggestions for clinical management

S Beyenburg, AJ Mitchell, D Schmidt, CE Elger… - Epilepsy & Behavior, 2005 - Elsevier
Up to 50 or 60% of patients with chronic epilepsy have various mood disorders including
depression and anxiety. Whereas the relationship between epilepsy and depression has …

Determinants of health‐related quality of life in pharmacoresistant epilepsy: results from a large multicenter study of consecutively enrolled patients using validated …

C Luoni, F Bisulli, MP Canevini, G De Sarro… - …, 2011 - Wiley Online Library
Purpose: To evaluate the relative contribution of demographic and epilepsy‐related
variables, depressive symptoms, and adverse effects (AEs) of antiepileptic drugs (AEDs) to …

Psychiatric and medical comorbidity and quality of life outcomes in childhood-onset epilepsy

CB Baca, BG Vickrey, R Caplan, SD Vassar… - Pediatrics, 2011 - publications.aap.org
OBJECTIVE: We compared associations of epilepsy remission status and severity as well as
psychiatric and other comorbidities with child and parent-proxy reports of health-related …