Abstract The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It
is a highly conserved evolutionary pathway of signal transmission from the cell membrane to …

The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the develo** child, and highlight the need for molecularly targeted …

While molecular subgrou** has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …

Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct
molecular subgroups. Whereas genomic characteristics of these subgroups are well …

PURPOSE SJMB03 (ClinicalTrials. gov identifier: NCT00085202) was a phase III risk-
adapted trial that aimed to determine the frequency and clinical significance of biological …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …

Background International consensus recognises four medulloblastoma molecular
subgroups: WNT (MB WNT), SHH (MB SHH), group 3 (MB Grp3), and group 4 (MB Grp4) …