Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

Numerous RNAs are exported from the nucleus, abnormalities of which lead to cellular
complications and diseases. How thousands of circular RNAs (circRNAs) are exported from …

Abstract SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in
the myelodysplastic syndromes (MDS). We have performed a comprehensive and …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …

The nuclear basket (NB) is an essential structure of the nuclear pore complex (NPC) and
serves as a dynamic and multifunctional platform that participates in various critical nuclear …

Cellular mechanisms that safeguard genome integrity are often subverted in cancer. To
identify cancer-related genome caretakers, we employed a convergent multi-screening …

DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is
crucial for cell viability and genome integrity. The readout of DSB repair may depend on …

R loops are an important source of genome instability, largely due to their negative impact
on replication progression. Yra1/ALY is an abundant RNA-binding factor conserved from …