Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

Impaired apoptosis is both critical in cancer development and a major barrier to effective
treatment. In response to diverse intracellular damage signals, including those evoked by …

Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is
commonly associated with tumor maintenance, progression, and chemoresistance. We …

Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …

Defects in apoptotic pathways can promote cancer cell survival and also confer resistance to
antineoplastic drugs. One pathway being targeted for antineoplastic therapy is the anti …

Multiple myeloma is a plasma cell malignancy characterized by complex heterogeneous
cytogenetic abnormalities. The bone marrow microenvironment promotes multiple myeloma …

Background Venetoclax is a highly selective, potent, oral BCL-2 inhibitor, which induces
apoptosis in multiple myeloma cells. Venetoclax plus bortezomib and dexamethasone has …

Apoptosis is essential for tissue homeostasis, particularly in the hematopoietic compartment,
where its impairment can elicit neoplastic or autoimmune diseases. Whether stressed cells …

BCL-2 family proteins dictate survival of human multiple myeloma cells, making them
attractive drug targets. Indeed, multiple myeloma cells are sensitive to antagonists that …

Disruption of the physiologic balance between cell proliferation and cell death is an
important step of cancer development. Increased resistance to apoptosis is a key oncogenic …