Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Abstract The Hodgkin and Reed/Sternberg (HRS) tumor cells of classical Hodgkin
lymphoma (HL) and the lymphocyte-predominant tumor cells of nodular lymphocyte …

Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF
interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact …

Classic Hodgkin lymphoma (cHL) constitutes a B-cell neoplasm derived from germinal
center lymphocytes. Despite high cure rates (80–90%) obtained with the current multiagent …

Recent discoveries shed light on molecular mechanisms responsible for classical Hodgkin
lymphoma (HL) development and progression, along with features of Hodgkin–Reed and …

Recently, we identified a novel chromosomal rearrangement in Hodgkin lymphoma (HL), t
(4; 8)(q27; q24), which targets homeobox gene ZHX2 at the recurrent breakpoint 8q24. This …

The survival of classical Hodgkin lymphoma (cHL) cells depends on activation of NF-κB,
JAK/STAT, and IRF4. Whereas these factors typically induce the master regulator of plasma …

The human family of ETS transcription factors numbers 28 genes which control multiple
aspects of development, notably the differentiation of blood and immune cells. Otherwise …

We recently found that FOXO1 repression contributes to the oncogenic program of classical
Hodgkin lymphoma (cHL). Interestingly, FOXO3A, another member of the FOXO family, was …

Ring1 and YY1 binding protein (RYBP) is a member of the Polycomb group (PcG) proteins
and regulates cell growth through both PcG-dependent and-independent mechanisms. Our …