Automated microfluidic cell culture of stem cell derived dopaminergic neurons

KIW Kane, EL Moreno, S Hachi, M Walter, J Jarazo… - Scientific reports, 2019 - nature.com
Parkinson's disease is a slowly progressive neurodegenerative disease characterised by
dysfunction and death of selectively vulnerable midbrain dopaminergic neurons and the …

Rapid, efficient, and simple motor neuron differentiation from human pluripotent stem cells

D Shimojo, K Onodera, Y Doi-Torii, Y Ishihara… - Molecular Brain, 2015 - Springer
Background Human pluripotent stem cells (hPSCs) are being applied in regenerative
medicine and for the in vitro modeling of human intractable disorders. In particular, neural …

[HTML][HTML] MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD

L Korn, AM Speicher, CB Schroeter, L Gola, T Kaehne… - Redox Biology, 2023 - Elsevier
Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases.
Mutations in the tau-encoding MAPT-gene lead to hereditary cases of frontotemporal lobar …

Age-induced midbrain-striatum assembloids model early phenotypes of Parkinson's disease

K Barmpa, C Saraiva, G Gomez-Giro, E Gabassi… - bioRxiv, 2023 - biorxiv.org
Abstract Parkinson's disease (PD), one of the most common aging-associated
neurodegenerative disorders, is characterised by nigrostriatal pathway dysfunction, caused …

Optically active bionanomachine interfaces build therapeutic nanonetworks for glioblastoma multiforme

A El Hamidieh, N Dietis, A Samoylenko… - 2022 IEEE 16th …, 2022 - ieeexplore.ieee.org
The evolution of Glioblastoma Multiforme (GBM) is defined by the dynamics of growing
bionanomachine networks in an interplay between" senders" or" transceivers" and" …

[PDF][PDF] Functional and Transcriptional Studies of Human Dopaminergic Neurons

M Birtele - 2020 - lup.lub.lu.se
Parkinson's Disease (PD) is the most common movement disorder and second most
common neurodegenerative disease. The principal hallmark of the pathology is represented …