According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …

Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals
triggering the release of mtDNA from mitochondria remain enigmatic. Here, we show that …

Genome sequences reveal that a deluge of DNA from organelles has constantly been
bombarding the nucleus since the origin of organelles. Recent experiments have shown that …

The occurrence of protein mediated lipid transfer between intracellular membranes has
been known since the late 1960's. Since these early discoveries, numerous proteins …

This volume and its companion, Volume 350, are specifically designed to meet the needs of
graduate students and postdoctoral students as well as researchers, by providing all the up …

All eukaryotic cells divide a finite number of times, although the mechanistic basis of this
replicative aging remains unclear. Replicative aging is accompanied by a reduction in …

Mutations in VPS13C cause early-onset, autosomal recessive Parkinson's disease (PD). We
have established that VPS13C encodes a lipid transfer protein localized to contact sites …

The endosymbiotic theory for the origin of mitochondria requires substantial modification.
The three identifiable ancestral sources to the proteome of mitochondria are proteins …

In eukaryotes, DNA is exchanged between endosymbiosis-derived compartments
(mitochondria and chloroplasts) and the nucleus. Organelle-to-nucleus DNA transfer …