Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

The existence of factors that stimulate blood vessel growth, thereby recruiting a neovascular
supply to nourish a growing tumour, was postulated many decades ago, although the …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in vivo. The tyrosine kinases Flt-1 (VEGFR-1) and Flk-1/KDR (VEGFR …

Angiogenesis plays critical roles in human physiology that range from reproduction and fetal
growth to wound healing and tissue repair. The sophisticated multistep process is tightly …

Role of vascular endothelial growth factor in the regulation of angiogenesis. Compelling
evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator …

Angiogenesis is essential for tumor growth. Vascular endothelial growth factor (VEGF) is the
most potent growth factor of tumor neovasculature, has been shown to be up-regulated in …

Growth of new blood vessels (angiogenesis), required for all tumor growth, is stimulated by
the expression of vascular endothelial growth factor (VEGF). VEGF is up-regulated in all …

Hypoxia‐inducible factor (HIF) plays an important role in renal tumourigenesis. In the
majority of clear cell RCC (ccRCC), the most frequent and highly vascularized RCC subtype …

Purpose To review the biology of renal cell carcinoma (RCC) leading to vascular endothelial
growth factor (VEGF) overexpression and the clinical results of VEGF blockade in metastatic …

BACKGROUND: Due to a dismal prognosis of advanced lung cancer, novel screening tools
and more effective treatments are clearly needed. Lately, an increasing number of tumour …