Leishmaniasis: where are we and where are we heading?

S Sasidharan, P Saudagar - Parasitology research, 2021‏ - Springer
Leishmaniasis is a zoonotic disease in humans caused by the bite of a parasite-infected
sandfly. The disease, widely referred to as “poor man's disease,” affects millions of people …

Berberis Vulgaris and Berberine: An Update Review

M Imenshahidi, H Hosseinzadeh - Phytotherapy research, 2016‏ - Wiley Online Library
Berberine is an isoquinoline alkaloid present in several plants, including Coptis sp. and
Berberis sp. Berberine is a customary component in Chinese medicine, and is characterized …

Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014‏ - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

Amelioration of IFN-γ and TNF-α-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway

M Cao, P Wang, C Sun, W He, F Wang - PloS one, 2013‏ - journals.plos.org
Intestinal barrier dysfunction occurs in many intestinal diseases, in which proinflammatory
cytokines play critical roles. However, researchers are still on the way to defining the …

[HTML][HTML] Plant-derived compounds in treatment of leishmaniasis

A Oryan - Iranian journal of veterinary research, 2015‏ - ncbi.nlm.nih.gov
Leishmaniasis is a neglected public health problem caused by the protozoan species
belonging to the genus Leishmania affecting mostly the poor populations of develo** …

Tackling drug resistance and other causes of treatment failure in leishmaniasis

GJ Wijnant, F Dumetz, L Dirkx, D Bulté… - Frontiers in Tropical …, 2022‏ - frontiersin.org
Leishmaniasis is a tropical infectious disease caused by the protozoan Leishmania parasite.
The disease is transmitted by female sand flies and, depending on the infecting parasite …

Effects of berberine in the gastrointestinal tract—a review of actions and therapeutic implications

C Chen, Z Yu, Y Li, J Fichna, M Storr - The American journal of …, 2014‏ - World Scientific
Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp.
and Berberis sp. In traditional medicine, extracts of berberine are used in the treatment of …

Berberine mediates tumor cell death by skewing tumor-associated immunosuppressive macrophages to inflammatory macrophages

D Shah, N Challagundla, V Dave, A Patidar, B Saha… - Phytomedicine, 2022‏ - Elsevier
Background Berberine is a plant-derived alkaloid with potent anti-cancer activities.
Berberine may redirect the tumor-promoting immunosuppressive M2 macrophages, to …

A review on new natural and synthetic anti-leishmanial chemotherapeutic agents and current perspective of treatment approaches.

N Majumder, A Banerjee, S Saha - Acta Tropica, 2023‏ - Elsevier
Leishmaniases are considered among the most neglected yet dangerous parasitic diseases
worldwide. According to the recent WHO report (Weekly Epidemiological Record, Sep …

Immunotherapy and targeted therapies in treatment of visceral leishmaniasis: current status and future prospects

OP Singh, S Sundar - Frontiers in immunology, 2014‏ - frontiersin.org
Visceral leishmaniasis (VL) is a vector-borne chronic infectious disease caused by the
protozoan parasite Leishmania donovani or Leishmania infantum. VL is a serious public …