The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia
nigra leading to disabling deficits. Dopamine neuron grafts may provide a significant …

How dopamine (DA) neuronal subtypes are specified remains unknown. In this study we
show a robust generation of functional DA neurons from human embryonic stem cells …

Dopaminergic (DA) neurons of the ventral midbrain (VM) play vital roles in the regulation of
voluntary movement, emotion and reward. They are divided into the A8, A9 and A10 …

Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a
promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation …

Dopaminergic neurons located in the ventral mesodiencephalon are essential for the control
of voluntary movement and the regulation of emotion, and are severely affected in …

The past two decades have seen an explosion in our understanding of the origin and
development of the midbrain dopamine system. Much of this work has been focused on the …

Parkinson's disease (PD) is a progressive neurodegenerative disorder whose etiology is not
understood. This disease occurs both sporadically and through inheritance of single genes …

Midbrain neurons synthesizing the neurotransmitter dopamine play a central role in the
modulation of different brain functions and are associated with major neurological and …