The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

DNA replication is essential for faithful transmission of genetic information and is intimately
tied to chromosome structure and function. Genome duplication occurs in a defined temporal …

Duplication of the genome in mammalian cells occurs in a defined temporal order referred to
as its replication-timing (RT) program. RT changes dynamically during development …

Mammalian genomes are replicated in a cell type-specific order and in coordination with
transcription and chromatin organization. Currently, single-cell replication studies require …

Nuclear lamin B1 (LMNB1) constitutes one of the major structural proteins in the lamina
mesh. We silenced the expression of LMNB1 by RNA interference in the colon cancer cell …

Advances in genomic studies have led to significant progress in understanding the
epigenetically controlled interplay between chromatin structure and nuclear functions …

The DNA replication program is, in part, determined by the epigenetic landscape that
governs local chromosome architecture and directs chromosome duplication. Replication …

Eukaryotes use a temporally regulated process, known as the replication timing program, to
ensure that their genomes are fully and accurately duplicated during S phase. Replication …

Replication of eukaryotic chromosomes occurs once every cell division cycle in normal cells
and is a tightly controlled process that ensures complete genome duplication. The origin …

All plants and animals must replicate their DNA, using a regulated process to ensure that
their genomes are completely and accurately replicated. DNA replication timing programs …