Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia
are the principal immune cells of the brain, and the first to respond to the pathophysiological …

Microglial research has entered a fertile, dynamic phase characterized by novel
technologies including two-photon imaging, whole-genome transcriptomic and epigenomic …

Cerebral ischemia triggers a powerful inflammatory reaction involving peripheral leukocytes
and brain resident cells that contribute to both tissue injury and repair. However, their …

Stroke remains a major cause of long-term disability and mortality worldwide. The immune
system plays an important role in determining the condition of the brain following stroke. As …

Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …

Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

The traditional view of the adult brain as a static organ has changed in the past three
decades, with the emergence of evidence that it remains plastic and has some regenerative …

Systemic transplantation of oxygen− glucose deprivation (OGD)-preconditioned primary
microglia enhances neurological recovery in rodent stroke models, albeit the underlying …

The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …

The limited success in understanding the pathophysiology of major depression may result
from excessive focus on the dysfunctioning of neurons, as compared with other types of …