The global prevalence of atrial fibrillation (AF) has increased substantially over the past
three decades and is currently approximately 60 million cases. Incident AF and its clinical …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Aging is the main risk factor for vascular disease and ensuing cardiovascular and
cerebrovascular events, the leading causes of death worldwide. In a progressively aging …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Cellular senescence is now considered an important driving mechanism for chronic lung
diseases, particularly chronic obstructive pulmonary disease (COPD) and idiopathic …

BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …