Toxoplasma gondii is a protozoan parasite of global importance. In the laboratory setting, T.
gondii is frequently used as a model pathogen to study mechanisms of T helper 1 (TH1) cell …

Humans and animals use the classical five senses of sight, sound, touch, smell and taste to
monitor their environment. The very survival of feral animals depends on these sensory …

Summary Toll-like receptor 11 (TLR11) recognizes T. gondii profilin (TgPRF) and is required
for interleukin-12 production and induction of immune responses that limit cyst burden in …

Toxoplasma is a highly successful parasite that establishes a life-long chronic infection. To
do this, it must carefully regulate immune activation and host cell effector mechanisms. Here …

Delivering macromolecules across biological barriers such as the blood–brain barrier limits
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …

Leishmania RNA virus (LRV) is an important virulence factor associated with the
development of mucocutaneous Leishmaniasis, a severe form of the disease. LRV-mediated …

TLRs play a central role in the innate recognition of pathogens and the activation of dendritic
cells (DCs). In this study, we establish that, in addition to TLR11, TLR12 recognizes the …

The balance between controlling infection and limiting inflammation is particularly
precarious in the brain because of its unique vulnerability to the toxic effects of inflammation …

Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's
population. Notably, very little is known about innate immune sensing mechanisms for this …

Tumor cells can successfully escape the host immune attack by inducing the production of
immunosuppressive cells and molecules, leading to an ineffective tumor treatment and poor …