The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

Membrane microdomains (rafts) remain one of the controversial issues in biophysics.
Fluorescent molecular probes, which make these lipid nanostructures visible through optical …

Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …

The plasma membrane (PM) is the biological membrane that separates the interior of all
cells from the outside. The PM is constituted of a huge diversity of proteins and lipids. In this …

Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

The fluid mosaic model of Singer and Nicolson (1972) is a commonly used representation of
the cell membrane structure and dynamics. However a number of features, the result of four …

The physiological importance of cholesterol in the cell plasma membrane has attracted
increased attention in recent years. Consequently, the use of methods of controlled …

Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …

This review deals with the effects of synthetic and natural fatty acids on the biophysical
properties of membranes, and on their implication on cell function. Natural fatty acids are …