The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Critical raw materials (CRMs) are essential in the development of novel high-tech
applications. They are essential in sustainable materials and green technologies, including …

Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …

Members of the major facilitator superfamily (MFS) of transport proteins are essential for the
movement of a wide range of substrates across biomembranes. As this transport requires a …

The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

In mammals, the kidney plays an essential role in maintaining blood homeostasis through
the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion …

Melatonin is present in virtually all organisms from bacteria to mammals, and it exhibits a
broad spectrum of biological functions, including synchronization of circadian rhythms and …

The human solute carriers (SLCs) comprise over 400 different transporters, organized into
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …

The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in
human physiology as the principal route for acquiring and retaining dietary nitrogen. A …