Recent progresses in the cyclization and oxidation of polyketide biosynthesis
B Zhang, HM Ge - Current Opinion in Chemical Biology, 2024 - Elsevier
Polyketides represent an important class of natural products, renowned for their intricate
structures and diverse biological activities. In contrast to common fatty acids, polyketides …
structures and diverse biological activities. In contrast to common fatty acids, polyketides …
The role and mechanisms of canonical and non-canonical tailoring enzymes in bacterial terpenoid biosynthesis
Y Kakumu, AA Chaudhri, EJN Helfrich - Natural Product Reports, 2025 - pubs.rsc.org
Covering: up to April 2024Terpenoids represent the largest and structurally most diverse
class of natural products. According to textbook knowledge, this diversity arises from a two …
class of natural products. According to textbook knowledge, this diversity arises from a two …
A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation …
The diterpene synthase AfAS was identified from Aspergillus fumigatiaffinis. Its amino acid
sequence and—according to a structural model—active site architecture are highly similar to …
sequence and—according to a structural model—active site architecture are highly similar to …
Subrutilane—A Hexacyclic Sesterterpene from Streptomyces subrutilus
B Gu, B Goldfuss, G Schnakenburg… - Angewandte Chemie …, 2023 - Wiley Online Library
Mining of a terpene synthase from Streptomyces subrutilus resulted in the identification of
the hexacyclic sesterterpene subrutilane, besides eight pentacyclic side products …
the hexacyclic sesterterpene subrutilane, besides eight pentacyclic side products …
Common Biosynthesis of Non‐Canonical C16 Terpenes through a Fragmentation‐Recombination Mechanism
The biosynthesis of six recently reported non‐canonical C16 sesquiterpenoids named after
ancient Greek philosophers, archimedene, aristotelene, eratosthenene, pythagorene, α …
ancient Greek philosophers, archimedene, aristotelene, eratosthenene, pythagorene, α …
Two Sesterterpene Synthases from Lentzea atacamensis Demonstrate the Role of Conformational Variability in Terpene Biosynthesis
Mining of two multiproduct sesterterpene synthases from Lentzea atacamensis resulted in
the identification of the synthases for lentzeadiene (LaLDS) and atacamatriene (LaATS). The …
the identification of the synthases for lentzeadiene (LaLDS) and atacamatriene (LaATS). The …
Biosynthesis of the Non‐Canonical C17 Sesquiterpenoids Chlororaphen A and B from Pseudomonas Chlororaphis
Chlororaphens A and B are structurally unique non‐canonical C17 sesquiterpenoids from
Pseudomonas chlororaphis that are made by two SAM‐dependent methyltransferases and a …
Pseudomonas chlororaphis that are made by two SAM‐dependent methyltransferases and a …
Genome Mining from Agriculturally Relevant Fungi Led to a d-Glucose Esterified Polyketide with a Terpene-like Core Structure
Comparison of biosynthetic gene clusters (BGCs) found in devastating plant pathogens and
biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome …
biocontrol fungi revealed an uncharacterized and conserved polyketide BGC. Genome …
Mechanistic characterisation of a sesquiterpene synthase for asterisca-1, 6-diene from the liverwort Radula lindenbergiana and implications for pentalenene …
A sesquiterpene synthase from the liverwort Radula lindenbergiana was characterised and
shown to produce the new sesquiterpene hydrocarbon (3R, 9R)-asterisca-1, 6-diene …
shown to produce the new sesquiterpene hydrocarbon (3R, 9R)-asterisca-1, 6-diene …
Telesco** a Prenyltransferase and a Diterpene Synthase to Transform Unnatural FPP Derivatives to Diterpenoids
H Struwe, H Li, F Schrödter, L Höft, J Fohrer… - Organic …, 2024 - ACS Publications
New diterpenoids are accessible from non-natural FPP derivatives as substrates for an
enzymatic elongation cyclization cascade using the geranylgeranyl pyrophosphate synthase …
enzymatic elongation cyclization cascade using the geranylgeranyl pyrophosphate synthase …