ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
The complementarity of DDR, nucleic acids and anti-tumour immunity
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
[HTML][HTML] Proteogenomic characterization of endometrial carcinoma
We undertook a comprehensive proteogenomic characterization of 95 prospectively
collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This …
collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This …
DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities
Y Abuetabh, HH Wu, C Chai, H Al Yousef… - … & molecular medicine, 2022 - nature.com
Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …
CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate
L Stolarova, P Kleiblova, M Janatova, J Soukupova… - Cells, 2020 - mdpi.com
Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …
DNA damage kinase signaling: checkpoint and repair at 30 years
From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
DNA damage sensing by the ATM and ATR kinases
In eukaryotic cells, maintenance of genomic stability relies on the coordinated action of a
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …
[HTML][HTML] ATM and ATR as therapeutic targets in cancer
AM Weber, AJ Ryan - Pharmacology & therapeutics, 2015 - Elsevier
In order to maintain genomic stability, cells have developed sophisticated signalling
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …
pathways to enable DNA damage or DNA replication stress to be resolved. Key mediators of …
CHK2 kinase in the DNA damage response and beyond
L Zannini, D Delia, G Buscemi - Journal of molecular cell …, 2014 - academic.oup.com
The serine/threonine kinase CHK2 is a key component of the DNA damage response. In
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …
human cells, following genotoxic stress, CHK2 is activated and phosphorylates> 20 proteins …
Recommendations for management of patients with neuroendocrine liver metastases
A Frilling, IM Modlin, M Kidd, C Russell… - The lancet …, 2014 - thelancet.com
Many management strategies exist for neuroendocrine liver metastases. These strategies
range from surgery to ablation with various interventional radiology procedures, and include …
range from surgery to ablation with various interventional radiology procedures, and include …