MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting

AA Bhat, O Afzal, M Afzal, G Gupta, R Thapa… - … -Research and Practice, 2024 - Elsevier
Lung cancer remains a formidable global health burden, necessitating a comprehensive
understanding of the underlying molecular mechanisms driving its progression. Recently …

From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer

MS Hussain, ASA Altamimi, M Afzal, I Kazmi… - … -Research and Practice, 2024 - Elsevier
Long non-coding RNAs (lncRNAs) have been demonstrated to have a crucial function in the
modulation of the activity of genes, impacting a variety of homeostatic processes involving …

Circular RNAs in the KRAS pathway: emerging players in cancer progression

MS Hussain, E Moglad, M Afzal, P Bansal… - … -Research and Practice, 2024 - Elsevier
Circular RNAs (circRNAs) have been recognized as key components in the intricate
regulatory network of the KRAS pathway across various cancers. The KRAS pathway, a …

PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities

MA Hakami, A Hazazi, FR Khan, O Abdulaziz… - … -Research and Practice, 2024 - Elsevier
The lncRNA PVT1 has emerged as a pivotal component in the intricate landscape of cancer
pathogenesis, particularly in lung cancer. PVT1, situated in the 8q24 chromosomal region …

Janus kinase/signal transducers and activator of transcription (JAK/STAT) and its role in Lung inflammatory disease

M Purohit, G Gupta, O Afzal, ASA Altamimi… - Chemico-biological …, 2023 - Elsevier
A key signaling channel for the signal transduction of several crucial cytokines implicated in
sepsis is the JAK/STAT system. Once cytokines attach to the proper receptors, JAK kinases …

HOTAIR: A key regulator of the Wnt/β-catenin signaling cascade in cancer progression and treatment

MA Hakami, A Hazazi, O Abdulaziz… - … -Research and Practice, 2024 - Elsevier
The long non-coding RNA (lncRNA) HOTAIR occupies a central position in the complex
domain of cancer biology, particularly concerning its intricate interplay with the Wnt/β …

Exosomal ncRNAs in liquid biopsies for lung cancer

MS Hussain, G Gupta, N Ghaboura, E Moglad… - Clinica chimica acta, 2024 - Elsevier
Exosomal non-coding RNAs (ncRNAs) have become essential contributors to advancing
and treating lung cancers (LCs). The development of liquid biopsies that utilize exosomal …

Targeting notch-related lncRNAs in cancer: insights into molecular regulation and therapeutic potential

R Siddique, G Kumar, MGM Johar, A Kumar… - … -Research and Practice, 2024 - Elsevier
Cancer is a group of diseases marked by unchecked cell proliferation and the ability for the
disease to metastasize to different body areas. Enhancements in treatment and early …

Ferroptosis and circular RNAs: new horizons in cancer therapy

AA Bhat, N Kukreti, M Afzal, A Goyal, R Thapa… - EXCLI …, 2024 - pmc.ncbi.nlm.nih.gov
Cancer poses intricate challenges to treatment due to its complexity and diversity.
Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues …

Targeting the Wnt/β-catenin cascade in osteosarcoma: The potential of ncRNAs as biomarkers and therapeutics

S Fuloria, G Yadav, SV Menon, H Ali, K Pant… - … -Research and Practice, 2024 - Elsevier
Osteosarcoma (OS) is a bone cancer which stems from several sources and presents with
diverse clinical features, making evaluation and treatment difficult. Chemotherapy tolerance …