In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …

Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use
as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding …

Amongst sulfur-and nitrogen-containing heterocyclic compounds, the 2-aminothiazole
scaffold is one of the characteristic structures in drug development as this essential …

Reactions of the Schiff base ligand derived from 4-acetyl-5, 6-diphenyl-3 (2H)-pyridazinone
and ethylenediamine with Ni (II) and Co (II) using different metal salts; NO 3−, AcO−, ClO 4 …

Introduction Dihydrofolate reductase (DHFR) plays an important role in the biosynthesis of
amino acid and folic acid. It participates by reducing dihydrofolate to tetrahydrofolate, in the …

Background: Dihydrofolate reductase (DHFR) is an indispensable enzyme required for the
survival of most prokaryotic and eukaryotic cells as it is involved in the biosynthesis of …

Metabolic reprogramming is a key hallmark of cancer and shifts cellular metabolism to meet
the demands of biomass production necessary for abnormal cell reproduction. One-carbon …

The dihydrofolate reductase (DHFR) is a significant target in cancer, microbial infection,
fungal infection, malaria, leishmaniasis, and tuberculosis, among other diseases. The DHFR …

Proteins are the most critical executive molecules by responding to the instructions stored in
the genetic materials in any form of life. More frequently, proteins do their jobs by acting as a …

Abstract New 2‐mercapto‐quinazolin‐4‐one analogs were synthesized and tested for their
in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and epidermal growth …