Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders
Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity
and mortality. The variety of metabolic illnesses can be addressed through personalized …
and mortality. The variety of metabolic illnesses can be addressed through personalized …
Type 2 diabetes mellitus in sub-Saharan Africa: challenges and opportunities
Type 2 diabetes mellitus (T2DM), which was once thought to be rare in sub-Saharan Africa
(SSA), is now well established in this region. The SSA region is undergoing a rapid but …
(SSA), is now well established in this region. The SSA region is undergoing a rapid but …
Ten years of EWAS
S Wei, J Tao, J Xu, X Chen, Z Wang, N Zhang… - Advanced …, 2021 - Wiley Online Library
Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation
variation in complex diseases for a decade, and epigenome as a research target has …
variation in complex diseases for a decade, and epigenome as a research target has …
Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts
E Fraszczyk, AMW Spijkerman, Y Zhang, S Brandmaier… - Diabetologia, 2022 - Springer
Aims/hypothesis Type 2 diabetes is a complex metabolic disease with increasing
prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic …
prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic …
Validation of an Integrated Genetic‐Epigenetic Test for the Assessment of Coronary Heart Disease
Background Coronary heart disease (CHD) is the leading cause of death in the world.
Unfortunately, many of the key diagnostic tools for CHD are insensitive, invasive, and costly; …
Unfortunately, many of the key diagnostic tools for CHD are insensitive, invasive, and costly; …
The emerging role of TXNIP in ischemic and cardiovascular diseases; a novel marker and therapeutic target
A Domingues, J Jolibois, P Marquet de Rougé… - International Journal of …, 2021 - mdpi.com
Thioredoxin interacting protein (TXNIP) is a metabolism-oxidative-and inflammation-related
marker induced in cardiovascular diseases and is believed to represent a possible link …
marker induced in cardiovascular diseases and is believed to represent a possible link …
Pathophysiology of type 2 diabetes in sub-Saharan Africans
Abstract Sub-Saharan Africa (SSA) is the region with the highest projected rates of increase
in type 2 diabetes (129% by 2045), which will exacerbate the already high prevalence of …
in type 2 diabetes (129% by 2045), which will exacerbate the already high prevalence of …
Epigenetics in precision nutrition
Precision nutrition is an emerging area of nutrition research, with primary focus on the
individual variability in response to dietary and lifestyle factors, which are mainly determined …
individual variability in response to dietary and lifestyle factors, which are mainly determined …
DNA methylation biomarkers of myocardial infarction and cardiovascular disease
Background The epigenetic landscape underlying cardiovascular disease (CVD) is not
completely understood and the clinical value of the identified biomarkers is still limited. We …
completely understood and the clinical value of the identified biomarkers is still limited. We …