Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Motile cells extend a leading edge by assembling a branched network of actin filaments that
produces physical force as the polymers grow beneath the plasma membrane. A core set of …

The actin cytoskeleton—a collection of actin filaments with their accessory and regulatory
proteins—is the primary force-generating machinery in the cell. It can produce pushing …

The Arp2/3 complex is a stable assembly of seven protein subunits including two actin-
related proteins (Arp2 and Arp3) and five novel proteins. Previous work showed that this …

▪ Abstract We review how motile cells regulate actin filament assembly at their leading edge.
Activation of cell surface receptors generates signals (including activated Rho family …

Although small GTP-binding proteins of the Rho family have been implicated in signaling to
the actin cytoskeleton, the exact nature of the linkage has remained obscure. We describe a …

The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin …

The leading edge (∼ 1 μm) of lamellipodia in Xenopus laevis keratocytes and fibroblasts
was shown to have an extensively branched organization of actin filaments, which we term …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

Background: The actin-related proteins Arp2 and Arp3 are part of a seven-protein complex
which is localized in the lamellipodia of a variety of cell types, and in actin-rich spots of …