Phenolic compounds: Current industrial applications, limitations and future challenges

BR Albuquerque, SA Heleno, MBPP Oliveira… - Food & function, 2021 - pubs.rsc.org
Phenolic compounds are natural bioactive molecules found mainly in plant tissues that have
shown interesting bioactivities, such as antioxidant, antimicrobial, anti-inflammatory, and …

Potential adverse effects of resveratrol: A literature review

A Shaito, AM Posadino, N Younes, H Hasan… - International journal of …, 2020 - mdpi.com
Due to its health benefits, resveratrol (RE) is one of the most researched natural
polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the …

Resveratrol: A double-edged sword in health benefits

B Salehi, AP Mishra, M Nigam, B Sener, M Kilic… - Biomedicines, 2018 - mdpi.com
Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) belongs to polyphenols' stilbenoids group,
possessing two phenol rings linked to each other by an ethylene bridge. This natural …

Fermentation transforms the phenolic profiles and bioactivities of plant-based foods

W Leonard, P Zhang, D Ying, B Adhikari, Z Fang - Biotechnology Advances, 2021 - Elsevier
Phenolics are a group of compounds derived from plants that have displayed potent
biological activities and health-promoting effects. Fermentation is one of the most …

A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Q Liu, Y Liu, G Li, O Savolainen, Y Chen… - Nature …, 2021 - nature.com
Isoflavonoids comprise a class of plant natural products with great nutraceutical,
pharmaceutical and agricultural significance. Their low abundance in nature and structural …

Engineering cellular metabolism

J Nielsen, JD Keasling - Cell, 2016 - cell.com
Metabolic engineering is the science of rewiring the metabolism of cells to enhance
production of native metabolites or to endow cells with the ability to produce new products …

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Q Liu, T Yu, X Li, Y Chen, K Campbell, J Nielsen… - Nature …, 2019 - nature.com
The production of bioactive plant compounds using microbial hosts is considered a safe,
cost-competitive and scalable approach to their production. However, microbial production …

Yeast systems biology: model organism and cell factory

J Nielsen - Biotechnology journal, 2019 - Wiley Online Library
For thousands of years, the yeast Saccharomyces cerevisiae (S. cerevisiae) has served as a
cell factory for the production of bread, beer, and wine. In more recent years, this yeast has …

Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications

J Lian, S Mishra, H Zhao - Metabolic engineering, 2018 - Elsevier
Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …