Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …

Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age
with a peak incidence in adolescents and young adults. The treatment of ES relies on a …

Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute
a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma …

Background Although there have been multiple randomised trials in newly diagnosed Ewing
sarcoma family of tumours (ESFT) and these have been conducted over many years and …

Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors
mainly occurring in children, adolescents and young adults. Current standard therapy …

There are currently no targeted delivery systems to satisfactorily treat bone-related
disorders. Many clinical drugs consisting of small organic molecules have a short circulation …

Primary malignant bone tumors in the pediatric to young adult populations are relatively
uncommon and account for about 6% of all cancers in those less than 20 years old [1] and …

Osteoimmunology was coined about twenty years ago to identify a strict cross talk between
bone niche and immune system both in physiological and pathological activities, including …