Air pollution exposure is estimated to contribute to approximately seven million early deaths
every year worldwide and more than 3% of disability-adjusted life years lost. Air pollution …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

In the burgeoning field of epigenetics, there are several methods available to determine the
methylation status of DNA samples. However, choosing the method that is best suited to …

DNA methylation is an epigenetic modification that plays an important role in regulating
gene expression and therefore a broad range of biological processes and diseases. DNA …

Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …

Epigenetic pathways are essential in different biological processes and in phenotype-
environment interactions in response to different stressors and they can induce phenotypic …

Background: Characterization of the epigenome is a primary interest for children's
environmental health researchers studying the environmental influences on human …

Ageing is a multifactorial process associated with reduced function and increased risk of
morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have …

The analysis of cell-free DNA (cfDNA) in plasma provides information on pathological
processes in the body. Blood cfDNA is in the form of nucleosomes, which maintain their …