Oxyresveratrol: Sources, productions, biological activities, pharmacokinetics, and delivery systems

K Likhitwitayawuid - Molecules, 2021 - mdpi.com
Oxyresveratrol has recently attracted much research attention due to its simple chemical
structure and diverse therapeutic potentials. Previous reviews describe the chemistry and …

Nanotechnology to improve the Alzheimer's disease therapy with natural compounds

MJ Ramalho, S Andrade, JA Loureiro… - Drug delivery and …, 2020 - Springer
Alzheimer's disease (AD) is a form of dementia with high impact worldwide, accounting with
more than 46 million cases. It is estimated that the number of patients will be four times …

The PERK-dependent molecular mechanisms as a novel therapeutic target for neurodegenerative diseases

W Rozpędek-Kamińska, N Siwecka… - International journal of …, 2020 - mdpi.com
Higher prevalence of neurodegenerative diseases is strictly connected with progressive
aging of the world population. Interestingly, a broad range of age-related …

Self-emulsifying drug delivery systems: An alternative approach to improve brain bioavailability of poorly water-soluble drugs through intranasal administration

S Meirinho, M Rodrigues, AO Santos, A Falcão… - Pharmaceutics, 2022 - mdpi.com
Efforts in discovering new and effective neurotherapeutics are made daily, although most fail
to reach clinical trials. The main reason is their poor bioavailability, related to poor aqueous …

Paradigms and success stories of natural products in drug discovery against neurodegenerative disorders (NDDs)

S Singh, S Chib, MJ Akhtar, B Kumar… - Current …, 2024 - benthamdirect.com
Neurodegenerative disorders (NDDs) are multifaceted complex disorders that have put a
great health and economic burden around the globe nowadays. The multi-factorial nature of …

Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats

D Junsaeng, T Anukunwithaya, P Songvut… - … and alternative medicine, 2019 - Springer
Background Oxyresveratrol is a major bioactive component derived from the heartwood of
Artocarpus lacucha. This compound exerts several biological activities, including …

Role of multi-targeted bioactive natural molecules and their derivatives in the treatment of Alzheimer's disease: an insight into structure-activity relationship

D Halder, S Das, J RS, A Joseph - Journal of Biomolecular …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is a complex neurodegenerative disorder involving cognitive
dysfunction like short-term memory and behavioral changes as the disease progresses due …

Oxyresveratrol-β-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies

T Agarwal, S Manandhar, AC Famurewa, PC Gurram… - Scientific Reports, 2024 - nature.com
Alzheimer's disease (AD) is associated with cognitive deficits and epigenetic deacetylation
that can be modulated by natural products. The role of natural oxyresveratrol-β-cyclodextrin …

Selective in vitro and in silico cholinesterase inhibitory activity of isoflavones and stilbenes from Belamcandae chinensis rhizoma

S Ślusarczyk, FSS Deniz, D Woźniak, Ł Pecio… - Phytochemistry …, 2019 - Elsevier
Isoflavonoids and stilbenes were suggested as potential lead structures for inhibition of
cholinesterases and in management of dementia. The Traditional Chinese (TCM) herb …

Neuroprotective effect of oxyresveratrol in rotenone-induced Parkinsonism rats

R Rodsiri, H Benya-Aphikul… - Natural Product …, 2020 - journals.sagepub.com
Oxyresveratrol, a polyphenolic compound, has been reported as having antioxidant and anti-
inflammatory effects. This study determined the neuroprotective effects of oxyresveratrol …