Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …

Background Neuronal networks in the brain include glutamatergic principal neurons and
GABAergic interneurons (GABA, γ-aminobutyric acid). The latter may be a minority cell type …

Recent success in identifying gene-regulatory elements in the context of recombinant adeno-
associated virus vectors has enabled cell-type-restricted gene expression. However, within …

Epileptic seizures represent dysfunctional neural networks dominated by excessive and/or
hypersynchronous activity. Recent progress in the field has outlined two concepts regarding …

Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world …

Neuronal networks consist of different types of neurons that all play their own role in order to
maintain proper network function. The two main types of neurons segregate in excitatory and …

Haploinsufficiency of the voltage-gated sodium channel NaV1. 1 causes Dravet syndrome,
an intractable developmental epilepsy syndrome with seizure onset in the first year of life …

Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizures, delayed
language and motor development, sleep disturbances, anxiety-like behaviour, severe …

Dravet Syndrome is an intractable form of childhood epilepsy associated with deleterious
mutations in SCN1A, the gene encoding neuronal sodium channel Nav1. 1. Earlier studies …

Mutations in brain isoforms of voltage-gated sodium channels have been identified in
patients with distinct epileptic phenotypes. Clinically, these patients often do not respond …