Biomedical applications and bioavailability of curcumin—An updated overview

SI Sohn, A Priya, B Balasubramaniam… - Pharmaceutics, 2021‏ - mdpi.com
Curcumin, a yellow-colored molecule derived from the rhizome of Curcuma longa, has been
identified as the bioactive compound responsible for numerous pharmacological activities of …

Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

S Abrahams, WL Haylett, G Johnson, JA Carr… - Neuroscience, 2019‏ - Elsevier
The global burden of neurodegenerative disorders has increased substantially over the past
2 decades due to rising rates of population aging. Although neurodegenerative disorders …

Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review

K Mahmood, KM Zia, M Zuber, M Salman… - International journal of …, 2015‏ - Elsevier
Turmeric (Curcuma longa) is a popular Indian spice that has been used for centuries in
herbal medicines for the treatment of a variety of ailments such as rheumatism, diabetic …

[HTML][HTML] Plant natural products: Promising resources for cancer chemoprevention

L Ma, M Zhang, R Zhao, D Wang, Y Ma, L Ai - Molecules, 2021‏ - mdpi.com
Cancer is a major factor threatening human health and life safety, and there is a lack of safe
and effective therapeutic drugs. Intervention and prevention in premalignant process are …

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner …

Y Li, J Li, S Li, Y Li, X Wang, B Liu, Q Fu… - Toxicology and Applied …, 2015‏ - Elsevier
Curcumin is a natural polyphenolic compound in Curcuma longa with beneficial effects on
neuronal protection. This study aims to investigate the action of curcumin in the …

The role of peroxiredoxin 6 in cell signaling

JA Arevalo, JP Vázquez-Medina - Antioxidants, 2018‏ - mdpi.com
Peroxiredoxin 6 (Prdx6, 1-cys peroxiredoxin) is a unique member of the peroxiredoxin family
that, in contrast to other mammalian peroxiredoxins, lacks a resolving cysteine and uses …

Cyanidin-3-glucoside activates Nrf2-antioxidant response element and protects against glutamate-induced oxidative and endoplasmic reticulum stress in HT22 …

M Sukprasansap, P Chanvorachote… - … medicine and therapies, 2020‏ - Springer
Abstract Background Cyanidin-3-glucoside (C3G), a major anthocyanin present in berries,
exhibits a strong antioxidant and has been shown to possess a neuroprotection. Prolonged …

Curcumin and its analogues protect from endoplasmic reticulum stress: Mechanisms and pathways

A Shakeri, MR Zirak, AW Hayes, R Reiter… - Pharmacological …, 2019‏ - Elsevier
The endoplasmic reticulum (ER), a cellular organelle with multiple functions, plays an
important role in several biological processes including protein folding, secretion, lipid …

[HTML][HTML] Clock protein Bmal1 and Nrf2 cooperatively control aging or oxidative response and redox homeostasis by regulating rhythmic expression of Prdx6

B Chhunchha, E Kubo, DP Singh - Cells, 2020‏ - mdpi.com
Many disorders of aging, including blinding-diseases, are associated with deficiency of brain
and muscle arnt-like protein 1 (Bmal1) and, thereby, dysregulation of antioxidant-defense …

Mechanisms underlying curcumin-induced neuroprotection in cerebral ischemia

F Fan, M Lei - Frontiers in Pharmacology, 2022‏ - frontiersin.org
Ischemic stroke is the leading cause of death and disability worldwide, and restoring the
blood flow to ischemic brain tissues is currently the main therapeutic strategy. However …