Maternal microbiota, early life colonization and breast milk drive immune development in the newborn

C Kalbermatter, N Fernandez Trigo… - Frontiers in …, 2021 - frontiersin.org
The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

Vitamin D and bronchial asthma: an overview of data from the past 5 years

SC Hall, DK Agrawal - Clinical therapeutics, 2017 - Elsevier
Purpose Vitamin D is a potent immunomodulator capable of dampening inflammatory
signals in several cell types involved in the asthmatic response. Its deficiency has been …

Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory

EL Bishop, A Ismailova, S Dimeloe… - Journal of Bone and …, 2021 - academic.oup.com
Regulation of immune function continues to be one of the most well recognized extraskeletal
actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells …

The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome

RE Hoeppli, D Wu, L Cook, MK Levings - Frontiers in immunology, 2015 - frontiersin.org
Regulatory T cells (Tregs) are suppressive T cells that have an essential role in maintaining
the balance between immune activation and tolerance. Their development, either in the …

Role of metabolism in the immunobiology of regulatory T cells

M Galgani, V De Rosa, A La Cava… - The Journal of …, 2016 - journals.aai.org
Intracellular metabolism is central to cell activity and function. CD4+ CD25+ regulatory T
cells (Tregs) that express the transcription factor FOXP3 play a pivotal role in the …

Regulatory T cells: serious contenders in the promise for immunological tolerance in transplantation

N Safinia, C Scotta, T Vaikunthanathan… - Frontiers in …, 2015 - frontiersin.org
Regulatory T cells (Tregs) play an important role in immunoregulation and have been shown
in animal models to promote transplantation tolerance and curb autoimmunity following their …

Vitamin D Actions on CD4+ T Cells in Autoimmune Disease

CE Hayes, SL Hubler, JR Moore, LE Barta… - Frontiers in …, 2015 - frontiersin.org
This review summarizes and integrates research on vitamin D and CD4+ T-lymphocyte
biology to develop new mechanistic insights into the molecular etiology of autoimmune …

Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects

L Malaguarnera - International Immunopharmacology, 2020 - Elsevier
The gut microbiota is crucial for host immune response, vitamin synthesis, short chain fatty
acids (SCFAs) production, intestinal permeability, nutrient digestion energy metabolism and …

Vitamin D over the first decade and susceptibility to childhood allergy and asthma

EM Hollams, SM Teo, M Kusel, BJ Holt, KE Holt… - Journal of Allergy and …, 2017 - Elsevier
Background Vitamin D (25 (OH) D) deficiency has been implicated as a possible risk factor
for asthma development, but studies at selected time points measuring 25 (OH) D levels …

Regulatory T cell stability and plasticity in atherosclerosis

AJ Ali, J Makings, K Ley - Cells, 2020 - mdpi.com
Regulatory T cells (Tregs) express the lineage-defining transcription factor FoxP3 and play
crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based …