Cellular states are determined by differential expression of the cell's proteins. The
relationship between protein and mRNA expression levels informs about the combined …

Genetically identical cells exposed to the same environmental conditions can show
significant variation in molecular content and marked differences in phenotypic …

A wide variety of biological experiments rely on the ability to express an exogenous gene in
a transgenic animal at a defined level and in a spatially and temporally controlled pattern …

Genetically identical cells and organisms exhibit remarkable diversity even when they have
identical histories of environmental exposure. Noise, or variation, in the process of gene …

Regeneration is the process by which organisms replace lost or damaged tissue, and
regenerative capacity can vary greatly among species, tissues and life stages. Tissue …

Spatiotemporal patterns of gene expression are fundamental to every developmental
program. The resulting macroscopic domains have been mainly characterized by their levels …

Transposable elements (TEs) are genomic parasites that selfishly replicate at the expense of
host fitness. Fifty years of evolutionary studies of TEs have concentrated on the deleterious …

Transcriptional regulation is an inherently noisy process. The origins of this stochastic
behavior can be traced to the random transitions among the discrete chemical states of …

Position-effect variegation (PEV) results when a gene normally in euchromatin is juxtaposed
with heterochromatin by rearrangement or transposition. When heterochromatin packaging …

DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that
duplicate megabase-sized chromosome segments at specific times during S-phase …