Every cell must solve the problem of how to fold its genome. We describe how the folded
state of chromosomes is the result of the combined activity of multiple conserved …

Enhancers are remotely located noncoding DNA sequences that regulate gene expression
in response to developmental, homeostatic, and environmental cues. Canonical short-range …

Enhancers are tissue-specific regulatory DNA elements that can activate transcription of
genes over distance. Their target genes most often are located in the same contact domain …

The cohesin protein complex extrudes chromatin loops, stop** at CTCF-bound sites, to
organize chromosomes into topologically associated domains, yet the biological …

Cell-type-specific gene activation is regulated by enhancers, sometimes located at large
genomic distances from target gene promoters. Whether distal enhancers require specific …

Transcription factors (TFs) bind genomic DNA regulating gene expression and
developmental programs in embryonic stem cells (ESCs). Even though comprehensive …