The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …

Alzheimer's disease (AD) is the most common form of dementia among the elderly. In AD
patients, memory loss is accompanied by the formation of beta-amyloid plaques and the …

The object recognition test (ORT) is a commonly used behavioral assay for the investigation
of various aspects of learning and memory in mice. The ORT is fairly simple and can be …

The nitric oxide (NO)/cGMP pathway has been extensively studied for its pivotal role in
synaptic plasticity and memory processes, resulting in an increase of cAMP response …

EVP-6124,(R)-7-chloro-N-quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide, is a novel
partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) that was evaluated …

The object recognition task (ORT) is a popular one-trial learning test for animals. In the
current study, we investigated several methodological issues concerning the task. Data was …

Rationale One of the major complaints most people face during aging is an impairment in
cognitive functioning. This has a negative impact on the quality of daily life and is even more …

Enhancing cyclic nucleotides signaling by inhibition of phosphodiesterases (PDEs) is known
to be beneficial in disorders associated with cognitive decline. The present study was …

Phosphodiesterase inhibitors (PDE-Is) enhance cAMP and/or cGMP signaling via reducing
the degradation of these cyclic nucleotides. Since both cAMP and cGMP signaling are …

Previous studies have demonstrated that cognitive function can be restored in mouse
models of Alzheimer's disease (AD) following administration of sildenafil, a specific PDE5 …