Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

The art and science of gene therapy has received much attention of late. The tragic death of
18-year-old Jesse Gelsinger, a volunteer in a Phase I clinical trial, has overshadowed the …

The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression.
However, a strong and universally responding system to express genes under Cre control is …

In multicellular organisms, dedicated regulatory circuits control cell type diversity and
responses. The crosstalk and redundancies within these circuits and substantial cellular …

Single-cell mouse embryos were infected in vitro with recombinant lentiviral vectors to
generate transgenic mice carrying the green fluorescent protein (GFP) gene driven by a …

Spillover events of avian influenza A viruses (IAVs) to humans could represent the first step
in a future pandemic. Several factors that limit the transmission and replication of avian IAVs …

A wide variety of biological experiments rely on the ability to express an exogenous gene in
a transgenic animal at a defined level and in a spatially and temporally controlled pattern …

Adult neurogenesis in the dentate gyrus may contribute to hippocampus-dependent
functions, yet little is known about when and how newborn neurons are functional because …

Abstract The Slee** Beauty (SB) transposon is a promising technology platform for gene
transfer in vertebrates; however, its efficiency of gene insertion can be a bottleneck in …

Lentiviral delivery of glial cell line–derived neurotrophic factor (lenti-GDNF) was tested for its
trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of …