COVID-19: a review on the novel coronavirus disease evolution, transmission, detection, control and prevention

A Sharma, I Ahmad Farouk, SK Lal - Viruses, 2021 - mdpi.com
Three major outbreaks of the coronavirus, a zoonotic virus known to cause respiratory
disease, have been reported since 2002, including SARS-CoV, MERS-CoV and the most …

SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies

AM Almehdi, G Khoder, AS Alchakee, AT Alsayyid… - Infection, 2021 - Springer
Purpose COVID-19 pandemic has emerged as a result of infection by the deadly pathogenic
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing enormous threats …

[HTML][HTML] Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

L Vangeel, W Chiu, S De Jonghe, P Maes, B Slechten… - Antiviral research, 2022 - Elsevier
We assessed the in vitro antiviral activity of remdesivir and its parent nucleoside GS-441524,
molnupiravir and its parent nucleoside EIDD-1931 and the viral protease inhibitor …

An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Y Liu, WT Soh, J Kishikawa, M Hirose, EE Nakayama… - Cell, 2021 - cell.com
Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein
prevent SARS-CoV-2 infection. However, the effects of antibodies against other spike …

Vaccines for COVID-19: a systematic review of immunogenicity, current development, and future prospects

Z Zhang, Q Shen, H Chang - Frontiers in immunology, 2022 - frontiersin.org
The persistent coronavirus disease 2019 (COVID-19), characterized by severe respiratory
syndrome, is caused by coronavirus 2 (SARS-CoV-2), and it poses a major threat to public …

Mutational dynamics of SARS-CoV-2: Impact on future COVID-19 vaccine strategies

N Faraji, T Zeinali, F Joukar, MS Aleali, N Eslami… - Heliyon, 2024 - cell.com
The rapid emergence of multiple strains of Severe Acute Respiratory Syndrome Coronavirus-
2 (SARS-CoV-2) has sparked profound concerns regarding the ongoing evolution of the …

S protein, ACE2 and host cell proteases in SARS-CoV-2 cell entry and infectivity; is soluble ACE2 a two blade sword? A narrative review

R Nejat, MF Torshizi, DJ Najafi - Vaccines, 2023 - mdpi.com
Since the spread of the deadly virus SARS-CoV-2 in late 2019, researchers have restlessly
sought to unravel how the virus enters the host cells. Some proteins on each side of the …

[HTML][HTML] Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain

ZP Schuurs, E Hammond, S Elli, TR Rudd… - Computational and …, 2021 - Elsevier
SARS-CoV-2 has rapidly spread throughout the world's population since its initial discovery
in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The …

[HTML][HTML] Unraveling the dynamics of Omicron (BA. 1, BA. 2, and BA. 5) waves and emergence of the deltacron variant: Genomic epidemiology of the SARS-CoV-2 …

AC Chrysostomou, B Vrancken, C Haralambous… - Viruses, 2023 - mdpi.com
Commencing in December 2019 with the emergence of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), three years of the coronavirus disease 2019 (COVID-19) …

SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY. 4.2

O Eales, AJ Page, L de Oliveira Martins, H Wang… - BMC infectious …, 2022 - Springer
Background Since the emergence of SARS-CoV-2, evolutionary pressure has driven large
increases in the transmissibility of the virus. However, with increasing levels of immunity …