More than 2 billion people are infected with helminth parasites across the globe. The
burgeoning drug resistance against current anthelmintics in parasitic worms of humans and …

Coumarins, also known as benzopyrones, are present in remarkable amounts in plants,
although their presence has also been detected in microorganisms and animal sources. The …

Lymphatic filariasis, onchocerciasis and loiasis caused by human filarial nematodes are
diseases of tropical and subtropical countries causing considerable morbidity. The available …

In the present study, methanolic extracts of roots of Vitex negundo L. and extracts of leaves
of Vitex negundo L., Ricinus communis L. and Aegle marmelos Corr. were explored for …

Modulation of immune functions by using herbal plants and their products has become
fundamental regime of therapeutic approach. Piper betle Linn.(Piperaceae) is a widely …

In the quest to discover novel scaffolds with leishmanicidal effects, a series of 23 compounds
containing the most promising 1, 2, 3-triazole and highly potent butenolide in one framework …

The present study is aimed to evaluate antifilarial activity of Xylocarpus granatum (fruit from
Andaman) against human lymphatic filarial parasite Brugia malayi in vivo. The in vitro …

Lymphatic filariasis continues to be a major health problem in tropical and subtropical
countries. A macrofilaricidal agent capable of eliminating adult filarial parasites is urgently …

In our continuing search for safe and efficacious antifilarials, a series of novel chalcone-
benzothiazole hybrids have been synthesized and evaluated for their Brugia malayi …

A series of 21 compounds of trisubstituted pyrimidine derivatives have been synthesized
and evaluated for their in vitro topoisomerase II inhibitory activity against filarial parasite …