The evolving role of tissue-resident memory T cells in infections and cancer

S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues

L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …

[HTML][HTML] Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

B Virassamy, F Caramia, P Savas, S Sant, J Wang… - Cancer Cell, 2023 - cell.com
CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (T RM) cell phenotype
are associated with favorable prognosis in patients with triple-negative breast cancer …

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

JT Crowl, M Heeg, A Ferry, JJ Milner, KD Omilusik… - Nature …, 2022 - nature.com
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

SN Christo, M Evrard, SL Park, LC Gandolfo… - Nature …, 2021 - nature.com
Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the
body. Although TRM cells in various organs rely on common transcriptional networks to …

Location, location, location: Tissue resident memory T cells in mice and humans

PA Szabo, M Miron, DL Farber - Science immunology, 2019 - science.org
The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

[HTML][HTML] Understanding subset diversity in T cell memory

SC Jameson, D Masopust - Immunity, 2018 - cell.com
Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …

Tissue-resident memory T cells in breast cancer control and immunotherapy responses

A Byrne, P Savas, S Sant, R Li, B Virassamy… - Nature reviews Clinical …, 2020 - nature.com
The presence of tumour-infiltrating lymphocytes (TILs) is associated with favourable
outcomes in patients with breast cancer as well as in those with other solid tumours. T cells …

Tissue-resident T cells and other resident leukocytes

D Masopust, AG Soerens - Annual review of immunology, 2019 - annualreviews.org
Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial
venous blood. Trm cells are heterogeneous but collectively constitute the most abundant …

The multifaceted role of tissue-resident memory T cells

SN Christo, SL Park, SN Mueller… - Annual Review of …, 2024 - annualreviews.org
Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell
populations. Of these, tissue-resident memory T (TRM) cells are strategically positioned in …