The hunger strikes back: an epigenetic memory for autophagy

P González-Rodríguez, J Füllgrabe… - Cell Death & …, 2023 - nature.com
Historical and demographical human cohorts of populations exposed to famine, as well as
animal studies, revealed that exposure to food deprivation is associated to lasting health …

[HTML][HTML] Dysregulation of different modes of programmed cell death by epigenetic modifications and their role in cancer

R Damiescu, T Efferth, M Dawood - Cancer Letters, 2024 - Elsevier
Modifications of epigenetic factors affect our lives and can give important information
regarding one's state of health. In cancer, epigenetic modifications play a crucial role, as …

Integrated miRNA and mRNA omics reveal neferine induced autophagy-dependent ferroptosis in human endometrial cancer in vivo and in vitro

F Ma, R Lu, R Ma, K Thakur, J Zhang, J Simal-Gandara… - Food Bioscience, 2024 - Elsevier
The most frequent type of gynecological cancer, endometrial cancer, seriously jeopardizes
the health of women. Lotus seed embryos contain large amounts of the compound neferine …

Aspirin exposure coupled with hypoxia interferes energy metabolism, antioxidant and autophagic processes and causes liver injury in estuarine goby Mugilogobius …

Y Wang, Y Zhao, W Gong, Y Hou, J Ren, C Duan… - Journal of Hazardous …, 2024 - Elsevier
Toxicity assessments of pollutants often overlook the impact of environmental factors like
hypoxia, which can alter chemical toxicity with unexpected consequences. In this study …

Targeting TRIP13 for overcoming anticancer drug resistance

L Zhao, S Ye, S **g, YJ Gao, T He - Oncology Reports, 2023 - spandidos-publications.com
Cancer is one of the greatest dangers to human wellbeing and survival. A key barrier to
effective cancer therapy is development of resistance to anti-cancer medications. In cancer …

Effects of Bryophyllum pinnatum on Dysfunctional Autophagy in Rats Lungs Exposed to Zinc Oxide Nanoparticles

TT Ijatuyi, AO Lawal, MO Akinjiyan, FM Ojo… - International …, 2024 - Elsevier
Lung inflammation as a result of exposure to toxicants is a major pathological problem.
Autophagy (AP) is a process of cell self-digestion and can be disrupted by environmental …

Targeting autophagy drug discovery: Targets, indications and development trends

M Jiang, W Wu, Z **ong, X Yu, Z Ye, Z Wu - European Journal of Medicinal …, 2024 - Elsevier
Autophagy plays a vital role in sustaining cellular homeostasis and its alterations have been
implicated in the etiology of many diseases. Drugs development targeting autophagy began …

[HTML][HTML] The Antitumor Potential of Sicilian Grape Pomace Extract: A Balance between ROS-Mediated Autophagy and Apoptosis

F Affranchi, D Di Liberto, M Lauricella, A D'Anneo… - Biomolecules, 2024 - mdpi.com
From the perspective of circular economy, it is extremely useful to recycle waste products for
human health applications. Among the health-beneficial properties of bioactive phyto …

The assessment of anti-melanoma potential of tigecycline—cellular and molecular studies of cell proliferation, apoptosis and autophagy on amelanotic and melanotic …

J Rok, J Kowalska, Z Rzepka, D Stencel, A Skorek… - Cells, 2023 - mdpi.com
High mortality, aggressiveness, and the relatively low effectiveness of therapy make
melanoma the most dangerous of skin cancers. Previously published studies presented the …

[HTML][HTML] The Interplay between Autophagy and Mitochondria in Cancer

A Zdanowicz, E Grosicka-Maciąg - International Journal of Molecular …, 2024 - mdpi.com
Besides producing cellular energy, mitochondria are crucial in controlling oxidative stress
and modulating cellular metabolism, particularly under stressful conditions. A key aspect of …