Differences between human and chimpanzee genomes and their implications in gene expression, protein functions and biochemical properties of the two species
MV Suntsova, AA Buzdin - BMC genomics, 2020 - Springer
Chimpanzees are the closest living relatives of humans. The divergence between human
and chimpanzee ancestors dates to approximately 6, 5–7, 5 million years ago. Genetic …
and chimpanzee ancestors dates to approximately 6, 5–7, 5 million years ago. Genetic …
[KNIHA][B] Good reasons for bad feelings: Insights from the frontier of evolutionary psychiatry
RM Nesse - 2019 - books.google.com
A founder of the field of evolutionary medicine uses his decades of experience as a
psychiatrist to provide a much-needed new framework for making sense of mental illness …
psychiatrist to provide a much-needed new framework for making sense of mental illness …
Epigenetics of neural differentiation: Spotlight on enhancers
M Giacoman-Lozano, C Meléndez-Ramírez… - Frontiers in Cell and …, 2022 - frontiersin.org
Neural induction, both in vivo and in vitro, includes cellular and molecular changes that
result in phenotypic specialization related to specific transcriptional patterns. These changes …
result in phenotypic specialization related to specific transcriptional patterns. These changes …
[HTML][HTML] 3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis
Elucidating the regulatory mechanisms of human brain evolution is essential to
understanding human cognition and mental disorders. We generated multi-omics profiles …
understanding human cognition and mental disorders. We generated multi-omics profiles …
[HTML][HTML] A high-resolution map of human enhancer RNA loci characterizes super-enhancer activities in cancer
Although enhancers play critical roles in cancer, quantifying enhancer activities in clinical
samples remains challenging, especially for super-enhancers. Enhancer activities can be …
samples remains challenging, especially for super-enhancers. Enhancer activities can be …
The developmental impacts of natural selection on human pelvic morphology
Evolutionary responses to selection for bipedalism and childbirth have shaped the human
pelvis, a structure that differs substantially from that in apes. Morphology related to these …
pelvis, a structure that differs substantially from that in apes. Morphology related to these …
Encoding signal propagation on topology-programmed DNA origami
Biological systems often rely on topological transformation to reconfigure connectivity
between nodes to guide the flux of molecular information. Here we develop a topology …
between nodes to guide the flux of molecular information. Here we develop a topology …
[HTML][HTML] The intricate dance of tumor evolution: Exploring immune escape, tumor migration, drug resistance, and treatment strategies
X Guo, X Bian, Y Li, X Zhu, X Zhou - … Acta (BBA)-Molecular Basis of Disease, 2024 - Elsevier
Recent research has unveiled fascinating insights into the intricate mechanisms governing
tumor evolution. These studies have illuminated how tumors adapt and proliferate by …
tumor evolution. These studies have illuminated how tumors adapt and proliferate by …
Ageing throughout history: the evolution of human lifespan
M Kyriazis - Journal of molecular evolution, 2020 - Springer
It is not surprising that one of the most complex phenomena in nature is that of ageing. It
does not only bear biological interest, but it is also associated with cultural, psychological …
does not only bear biological interest, but it is also associated with cultural, psychological …
Enhancer pleiotropy, gene expression, and the architecture of human enhancer–gene interactions
Enhancers are often studied as noncoding regulatory elements that modulate the precise
spatiotemporal expression of genes in a highly tissue-specific manner. This paradigm has …
spatiotemporal expression of genes in a highly tissue-specific manner. This paradigm has …