Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

The histaminergic system in the brain is a phylogenetically old group of neurons that project
to most of the central nervous system. It holds a key position in the regulation of basic body …

Histamine-releasing neurons are located exclusively in the TM of the hypothalamus, from
where they project to practically all brain regions, with ventral areas (hypothalamus, basal …

1. The repolarization of the action potential, and a fast after‐hyperpolarization (ahp) were
studied in CA1 pyramidal cells (n= 76) in rat hippocampal slices (28‐37 degrees C). Single …

Emotion enhances our ability to form vivid memories of even trivial events. Norepinephrine
(NE), a neuromodulator released during emotional arousal, plays a central role in the …

Experiments using intracellular recording techniques were performed on rat hippocampal
neurones in vitro, to study the discharge properties of these cells. When CA 1 pyramidal …

The hippocampal pyramidal cells provide an example of how multiple potassium (K)
currents co-exist and function in central mammalian neurones. The data come from CA1 and …

It is clear from the preceding overview of histamine receptor pharmacology that research into
the pharmacology of histamine receptors is at an exciting stage of development. The rapid …