Multi-objective goal-directed optimization of de novo stable organic radicals for aqueous redox flow batteries

SS SV, JN Law, CE Tripp, D Duplyakin… - Nature Machine …, 2022 - nature.com
Advances in the field of goal-directed molecular optimization offer the promise of finding
feasible candidates for even the most challenging molecular design applications. One …

Molsearch: search-based multi-objective molecular generation and property optimization

M Sun, J **ng, H Meng, H Wang, B Chen… - Proceedings of the 28th …, 2022 - dl.acm.org
Leveraging computational methods to generate small molecules with desired properties has
been an active research area in the drug discovery field. Towards real-world applications …

VGAE-MCTS: A new molecular generative model combining the variational graph Auto-Encoder and monte carlo tree search

H Iwata, T Nakai, T Koyama, S Matsumoto… - Journal of Chemical …, 2023 - ACS Publications
Molecular generation is crucial for advancing drug discovery, materials science, and
chemical exploration. It expedites the search for new drug candidates, facilitates tailored …

JANUS: parallel tempered genetic algorithm guided by deep neural networks for inverse molecular design

AK Nigam, R Pollice, A Aspuru-Guzik - arxiv preprint arxiv:2106.04011, 2021 - arxiv.org
Inverse molecular design, ie, designing molecules with specific target properties, can be
posed as an optimization problem. High-dimensional optimization tasks in the natural …

An In-depth Summary of Recent Artificial Intelligence Applications in Drug Design

Y Zhang - arxiv preprint arxiv:2110.05478, 2021 - arxiv.org
As a promising tool to navigate in the vast chemical space, artificial intelligence (AI) is
leveraged for drug design. From the year 2017 to 2021, the number of applications of …

[BOOK][B] Machine Learning on Drug Discovery: Algorithms and Applications

M Sun - 2022 - search.proquest.com
Drug development is an expensive and time-consuming process where thousands of
chemical compounds are being tested and experiments being conducted in order to find out …