Enzymes, reacting with organophosphorus compounds as detoxifiers: diversity and functions
I Lyagin, E Efremenko - International Journal of Molecular Sciences, 2021 - mdpi.com
Organophosphorus compounds (OPCs) are able to interact with various biological targets in
living organisms, including enzymes. The binding of OPCs to enzymes does not always lead …
living organisms, including enzymes. The binding of OPCs to enzymes does not always lead …
Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors
IN Korkmaz, C Türkeş, Y Demir… - … of Biochemical and …, 2022 - Wiley Online Library
Abstract Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium‐
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
Paraoxonase 3: Structure and its role in pathophysiology of coronary artery disease
K Priyanka, S Singh, K Gill - Biomolecules, 2019 - mdpi.com
Spanning three decades in research, Paraoxonases (PON1) carried potential of dealing with
neurotoxicity of organophosphates entering the circulation and preventing cholinergic crisis …
neurotoxicity of organophosphates entering the circulation and preventing cholinergic crisis …
Active site engineering of Zn-doped mesoporous ceria toward highly efficient organophosphorus hydrolase-mimicking nanozyme
Hydrolase-mimicking nanozymes have received increasing attention in recent years, but the
effective rational design and development of these materials has not been realized, as they …
effective rational design and development of these materials has not been realized, as they …
Plasma glycation adducts and various RAGE isoforms are intricately associated with oxidative stress and inflammatory markers in type 2 diabetes patients with …
Background The secondary vascular complications in diabetes mellitus (DM) are contributed
by acute as well as inflammatory responses which get activated due to interaction between …
by acute as well as inflammatory responses which get activated due to interaction between …
Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity
Reduced activity of paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-associated
enzyme, has been implicated in the development of atherosclerosis. Post-translational …
enzyme, has been implicated in the development of atherosclerosis. Post-translational …
Fused human paraoxonase 1 as a prophylactic agent against organophosphate poisoning
Organophosphates (OPs) are highly neurotoxic compounds and certain OP-compounds are
also exploited as a weapon of mass destruction and chemical warfare in terrorist attacks …
also exploited as a weapon of mass destruction and chemical warfare in terrorist attacks …
Crosstalk between adipokines and paraoxonase 1: a new potential axis linking oxidative stress and inflammation
Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated protein that endows
its carrier with (lipo-) lactonase-dependent antioxidative features. Low levels of PON1 …
its carrier with (lipo-) lactonase-dependent antioxidative features. Low levels of PON1 …
[HTML][HTML] Molecular Structure of Paraoxonase-1 and Its Modifications in Relation to Enzyme Activity and Biological Functions—A Comprehensive Review
D Lewoń-Mrozek, J Kurzynoga, P Jędrzejewski… - International Journal of …, 2024 - mdpi.com
PON1 is a Ca2+-dependent enzyme that indicates a hydrolytic activity towards a broad
spectrum of substrates. The mechanism of hydrolysis catalyzed by this enzyme is poorly …
spectrum of substrates. The mechanism of hydrolysis catalyzed by this enzyme is poorly …
Role of paraoxonase 1 in organophosphate G-series nerve agent poisoning and future therapeutic strategies
Chemical warfare nerve agents (CWNA) are neurotoxic chemicals unethically used as
agents of mass destruction by terrorist outfits and during war. The available antidote against …
agents of mass destruction by terrorist outfits and during war. The available antidote against …