Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that
build the conceptus, yet how to capture this property in vitro remains incompletely …

Embryonic stem cells (ESCs) are derived from the pre-implantation mammalian blastocyst.
At this point in time, the newly formed embryo is concerned with the generation and …

INTRODUCTION Early mammalian development requires the formation of embryonic and
extraembryonic tissues and a highly coordinated partnership between them. This close …

In mammalian embryos, proper zygotic genome activation (ZGA) underlies totipotent
development. Double homeobox (DUX)-family factors participate in ZGA, and mouse Dux is …

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …

Generating cells with the molecular and functional properties of embryo cells and with full
developmental potential is an aim with fundamental biological significance. Here we report …

Embryonic stem cells (ESCs) exist in at least two states that transcriptionally resemble
different stages of embryonic development. Naïve ESCs resemble peri-implantation stages …

Activation of the FGF signaling pathway during preimplantation development of the mouse
embryo is known to be essential for differentiation of the inner cell mass and the formation of …