Ruthenium complexes as anticancer agents: A brief history and perspectives

SY Lee, CY Kim, TG Nam - Drug design, development and therapy, 2020 - Taylor & Francis
Platinum (Pt)-based anticancer drugs such as cisplatin have been used to treat various
cancers. However, they have some limitations including poor selectivity and toxicity towards …

Advancement of metal compounds as therapeutic and diagnostic metallodrugs: Current frontiers and future perspectives

I Yousuf, M Bashir, F Arjmand, S Tabassum - Coordination Chemistry …, 2021 - Elsevier
Coordination compounds on account of distinctive features of metal ions that include
variable oxidation states, diverse range of geometries and coordination numbers …

[HTML][HTML] Copper (II) phenanthroline-based complexes as potential anticancer drugs: a walkthrough on the mechanisms of action

S Masuri, P Vaňhara, MG Cabiddu, L Moráň, J Havel… - Molecules, 2021 - mdpi.com
Copper is an endogenous metal ion that has been studied to prepare a new antitumoral
agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS …

Noble metals based bimetallic and trimetallic nanoparticles: controlled synthesis, antimicrobial and anticancer applications

S Ali, AS Sharma, W Ahmad, M Zareef… - Critical reviews in …, 2021 - Taylor & Francis
Noble bimetallic and trimetallic nanoparticles (NBT-NPs) have superior biomedical
applications as compared to their monometallic counterparts. The performance of these …

Metal-based BODIPY derivatives as multimodal tools for life sciences

B Bertrand, K Passador, C Goze, F Denat… - Coordination Chemistry …, 2018 - Elsevier
Abstract Nowadays, 4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene–better known as BODIPY
radical dot–is at the forefront of fluorophores for life sciences. Indeed, its high brightness, its …

Evaluation of central-metal effect on anticancer activity and mechanism of action of isostructural Cu (II) and Ni (II) complexes containing pyridine-2, 6-dicarboxylate

S Abdolmaleki, A Panjehpour, S Khaksar… - European Journal of …, 2023 - Elsevier
Abstract Two Cu (II)(C1) and Ni (II)(C2) complexes were designed through the one-pot
reaction of pyridine-2, 6-dicarboxylic acid and 2-aminobenzimidazole respectively with …

Recent advances in drug discovery against Mycobacterium tuberculosis: Metal-based complexes

CB Scarim, RL de Farias, AV de Godoy Netto… - European Journal of …, 2021 - Elsevier
Metal-based drugs are privileged motifs that act as primary pharmacophores in bioactive
compounds for various diseases, including tuberculosis (TB). This potentially life-threatening …

Gallium as an Antibacterial Agent: A DFT/SMD Study of the Ga3+/Fe3+ Competition for Binding Bacterial Siderophores

N Kircheva, T Dudev - Inorganic Chemistry, 2020 - ACS Publications
The urgency of finding novel antibacterial drugs (not only antibiotics), exhibiting different
mechanisms of therapeutic action, is significant and has served as a premise for recognizing …

Hypotoxic copper complexes with potent anti-metastatic and anti-angiogenic activities against cancer cells

X Shi, Z Chen, Y Wang, Z Guo, X Wang - Dalton transactions, 2018 - pubs.rsc.org
Tumor metastasis and angiogenesis are the major obstacles in anticancer therapy. A series
of phenanthroline copper (II) complexes with different alkyl chains (CPTn, n= 1, 4, 6, 8) are …

A gallium (III) complex that engages protein disulfide isomerase A3 (PDIA3) as an anticancer target

HY Yin, JJ Gao, X Chen, B Ma, ZS Yang… - Angewandte Chemie …, 2020 - Wiley Online Library
Gallium (III)‐based drugs have gained momentum in cancer therapy due to their iron‐
dependent anticancer activity. Judicious choice of ligands is critical for improved oral …