Aspergillus fumigatus and aspergillosis: From basics to clinics
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …
causing numerous invasive infections and a notable mortality in humans, especially in …
Emerging threat of triazole-resistant Aspergillus fumigatus
Invasive aspergillosis is a leading cause of morbidity and mortality among
immunocompromised populations and is predicted to cause more than 200 000 life …
immunocompromised populations and is predicted to cause more than 200 000 life …
Trichophyton rubrum azole resistance mediated by a new ABC transporter, TruMDR3
M Monod, M Feuermann, K Salamin… - Antimicrobial agents …, 2019 - Am Soc Microbiol
The mechanisms of terbinafine resistance in a set of clinical isolates of Trichophyton rubrum
have been studied recently. Of these isolates, TIMM20092 also showed reduced sensitivity …
have been studied recently. Of these isolates, TIMM20092 also showed reduced sensitivity …
Identification of Aspergillus fumigatus multidrug transporter genes and their potential involvement in antifungal resistance
Aspergillus fumigatus can cause severe fatal invasive aspergillosis in immunocompromised
patients but is also found in the environment. A. fumigatus infections can be treated with …
patients but is also found in the environment. A. fumigatus infections can be treated with …
Contributions of Aspergillus fumigatus ATP-binding cassette transporter proteins to drug resistance and virulence
In yeast cells such as those of Saccharomyces cerevisiae, expression of ATP-binding
cassette (ABC) transporter proteins has been found to be increased and correlates with a …
cassette (ABC) transporter proteins has been found to be increased and correlates with a …
Characterization of the efflux capability and substrate specificity of Aspergillus fumigatus PDR5-like ABC transporters expressed in Saccharomyces cerevisiae
This research analyzed six Aspergillus fumigatus genes encoding putative efflux proteins for
their roles as transporters. Th e A. fumigatus genes abcA, abcC, abcF, abcG, abcH, and abcI …
their roles as transporters. Th e A. fumigatus genes abcA, abcC, abcF, abcG, abcH, and abcI …
Phenotypic plasticity and the evolution of azole resistance in Aspergillus fumigatus; an expression profile of clinical isolates upon exposure to itraconazole
MWJ Hokken, J Zoll, JPM Coolen, BJ Zwaan… - BMC genomics, 2019 - Springer
Background The prevalence of azole resistance in clinical and environmental Aspergillus
fumigatus isolates is rising over the past decades, but the molecular basis of the …
fumigatus isolates is rising over the past decades, but the molecular basis of the …
PDR Transporter ABC1 Is Involved in the Innate Azole Resistance of the Human Fungal Pathogen Fusarium keratoplasticum
Fusarium keratoplasticum is arguably the most common Fusarium solani species complex
(FSSC) species associated with human infections. Invasive fusariosis is a life-threatening …
(FSSC) species associated with human infections. Invasive fusariosis is a life-threatening …
Bioinformatic analysis of the ABC transporter protein family and their function in Penicillium digitatum
X Shen, X Tan, Z Wang, K Meng, N Tao - Physiological and Molecular Plant …, 2023 - Elsevier
ATP-binding cassette transporter (ABC transporter) has prominent effects on the normal
growth, development, substance transport and drug detoxification of organisms. However …
growth, development, substance transport and drug detoxification of organisms. However …
The PDR-type ABC transporters AtrA and AtrG are involved in azole drug resistance in Aspergillus oryzae
D Miura, K Sugiyama, A Ito… - Bioscience …, 2018 - academic.oup.com
For strain improvement of Aspergillus oryzae, development of the transformation system is
essential, wherein dominant selectable markers, including drug-resistant genes, are …
essential, wherein dominant selectable markers, including drug-resistant genes, are …