The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

The human gene catalogue is essentially complete, but we lack an equivalently vetted
inventory of bona fide human enhancers. Hundreds of thousands of candidate enhancers …

Spatiotemporal chromatin reorganization during hematopoietic differentiation has not been
comprehensively characterized, mainly because of the large numbers of starting cells …

Cancer development and progression are demarcated by transcriptional dysregulation,
which is largely attributed to aberrant chromatin architecture. Recent transformative …

The application of immunotherapy in tumor, especially immune checkpoint inhibitors (ICIs),
has played an important role in the treatment of advanced unresectable liver cancer …

Despite the development of several Fms-like tyrosine kinase 3 (FLT3) inhibitors that have
improved outcomes in patients with FLT3-mutant acute myeloid leukemia (AML), drug …

FISH analysis using MYC break-apart probes is a widely used technique to assess for MYC
rearrangement (MYC-R). Occasionally, FISH results in atypical signal patterns, such as gain …

Acute myeloid leukemia (AML) is a group of highly aggressive malignancies with a 5-year
overall survival of less than 40%. Cell overgrowth with defective apoptosis is a hallmark of …

Interferon regulatory factor-8 (IRF8) is the lineage determining transcription factor for the
type one classical dendritic cell (cDC1) subset, a terminal selector for plasmacytoid dendritic …