Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Abnormal deposition of misprocessed and aggregated proteins is a common final pathway
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …

Hyperphosphorylation and aggregation of the microtubule‐associated protein tau in brain,
are pathological hallmarks of a large family of neurodegenerative disorders, named …

Alzheimer's disease (AD) is the most common form of dementia. The pathological hallmarks
of AD are amyloid plaques [aggregates of amyloid‐beta (Aβ)] and neurofibrillary tangles …

Tau, a microtubule-associated protein promotes assembly and stability of microtubules
which is related to axoplasmic flow and critical neuronal activities upon physiological …

In this chapter, we provide a review of the challenges and advances in develo**
successful PET imaging agents for 3 major types of aggregated amyloid proteins: amyloid …

With increased research funding for Alzheimer's disease (AD) and related disorders across
the globe, large amounts of data are being generated. Several studies employed machine …

The microtubule associated protein tau plays a critical role in the pathogenesis of
neurodegenerative disease. Recent studies suggest that tau also plays a role in disorders of …

Tau, a microtubule-associated protein predominantly localized in neuronal axons, plays a
crucial role in promoting microtubule assembly, stabilizing their structure, and participating …

All tauopathies, including Alzheimer's disease (AD), are characterized by the intracellular
accumulation of abnormal forms of tau protein in neurons and glial cells, which negatively …