Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

F Violi, V Cammisotto, S Bartimoccia… - Nature reviews …, 2023 - nature.com
Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

[HTML][HTML] Haemostasis in cirrhosis: understanding destabilising factors during acute decompensation

A Zanetto, P Northup, L Roberts, M Senzolo - Journal of Hepatology, 2023 - Elsevier
Hospitalised patients with decompensated cirrhosis are in a rebalanced haemostatic state
due to a parallel decline in both pro-and anti-haemostatic pathways. However, this …

[PDF][PDF] Impact of alcohol use disorder treatment on clinical outcomes among patients with cirrhosis

S Rogal, A Youk, H Zhang, WF Gellad, MJ Fine… - …, 2020 - Wiley Online Library
Background and Aims Despite the significant medical and economic consequences of
coexisting alcohol use disorder (AUD) in patients with cirrhosis, little is known about AUD …

Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences

T Lisman, RJ Porte - Blood, The Journal of the American …, 2010 - ashpublications.org
Patients with liver disease frequently acquire a complex disorder of hemostasis secondary to
their disease. Routine laboratory tests such as the prothrombin time and the platelet count …

Concepts and controversies in haemostasis and thrombosis associated with liver disease: Proceedings of the 7th International Coagulation in Liver Disease …

NM Intagliata, CK Argo, JG Stine… - Thrombosis and …, 2018 - thieme-connect.com
Patients with acute and chronic liver disease frequently acquire unique changes in
haemodynamic and haemostatic pathways that may result in life-threatening bleeding and …

[PDF][PDF] Coagulation parameters and major bleeding in critically ill patients with cirrhosis

A Drolz, T Horvatits, K Roedl, K Rutter, K Staufer… - …, 2016 - Wiley Online Library
Disturbances of coagulation and hemostasis are common in patients with liver cirrhosis. The
typical laboratory pattern mimics disseminated intravascular coagulation (DIC). The aim of …

Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia

H Fukui - World journal of hepatology, 2015 - pmc.ncbi.nlm.nih.gov
A “leaky gut” may be the cutting edge for the passage of toxins, antigens or bacteria into the
body, and may play a pathogenic role in advanced liver cirrhosis and its complications …

Coagulation disorders in liver disease

L Amitrano, MA Guardascione… - Seminars in liver …, 2002 - thieme-connect.com
The liver plays a central role in the clotting process, and acute and chronic liver diseases are
invariably associated with coagulation disorders due to multiple causes: decreased …

Infection, coagulation, and variceal bleeding in cirrhosis

U Thalheimer, CK Triantos, DN Samonakis, D Patch… - Gut, 2005 - gut.bmj.com
Bacterial infections in cirrhotic patients are common. There is a predisposition to intestinal
bacterial overgrowth, intestinal dysmotility, and increased intestinal permeability, all leading …

Thrombin-activatable fibrinolysis inhibitor deficiency in cirrhosis is not associated with increased plasma fibrinolysis

T Lisman, FWG Leebeek, LO Mosnier, BN Bouma… - Gastroenterology, 2001 - Elsevier
Background & Aims: The bleeding tendency of patients suffering from cirrhosis is in part
ascribed to accelerated fibrinolysis. In this study, the role of the recently discovered inhibitor …