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BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease
BACE1 (β-secretase, memapsin 2, Asp2) has emerged as a promising target for the
treatment of Alzheimer's disease. BACE1 is an aspartic protease which functions in the first …
treatment of Alzheimer's disease. BACE1 is an aspartic protease which functions in the first …
[HTML][HTML] Corilagin, a promising medicinal herbal agent
X Li, Y Deng, Z Zheng, W Huang, L Chen… - Biomedicine & …, 2018 - Elsevier
Corilagin, a gallotannin, is one of the major active components of many
ethnopharmacological plants. It was isolated from Caesalpinia coriaria (Jacq.) Willd.(dividivi) …
ethnopharmacological plants. It was isolated from Caesalpinia coriaria (Jacq.) Willd.(dividivi) …
Corilagin in cancer: a critical evaluation of anticancer activities and molecular mechanisms
Corilagin (β-1-O-galloyl-3, 6-(R)-hexahydroxydiphenoyl-d-glucose), an ellagitannin, is one
of the major bioactive compounds present in various plants. Ellagitannins belong to the …
of the major bioactive compounds present in various plants. Ellagitannins belong to the …
Therapeutic potential of mitophagy-inducing microflora metabolite, urolithin A for Alzheimer's disease
Mitochondrial dysfunction including deficits of mitophagy is seen in aging and
neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally …
neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally …
Geraniin protects high-fat diet-induced oxidative stress in Sprague Dawley rats
Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has
been shown to possess significant antioxidant activity in vitro and recently been recognized …
been shown to possess significant antioxidant activity in vitro and recently been recognized …
Pharmacogenomics of Alzheimer's disease: Novel therapeutic strategies for drug development
R Cacabelos, P Cacabelos, C Torrellas… - … in Drug Discovery and …, 2014 - Springer
Alzheimer's disease (AD) is a major problem of health and disability, with a relevant
economic impact on our society. Despite important advances in pathogenesis, diagnosis …
economic impact on our society. Despite important advances in pathogenesis, diagnosis …
[HTML][HTML] An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages
YD Boakye, L Groyer, EH Heiss - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Abstract Background An extract of Phyllanthus muellerianus and its constituent geraniin
have been reported to exert anti-inflammatory activity in vivo. However, orally consumed …
have been reported to exert anti-inflammatory activity in vivo. However, orally consumed …
18KHT01, a potent anti-obesity polyherbal formulation
Obesity is a life-threatening metabolic disorder necessitating urgent development of safe
and effective therapy. Currently, limited such therapeutic measures are available for obesity …
and effective therapy. Currently, limited such therapeutic measures are available for obesity …
Urolithins: A prospective alternative against brain aging
L An, Q Lu, K Wang, Y Wang - Nutrients, 2023 - mdpi.com
The impact of host–microbiome interactions on cognitive health and disease has received
increasing attention. Microbial-derived metabolites produced in the gut are one of crucial …
increasing attention. Microbial-derived metabolites produced in the gut are one of crucial …
Ellagitannin geraniin: a review of the natural sources, biosynthesis, pharmacokinetics and biological effects
HS Cheng, SH Ton, K Abdul Kadir - Phytochemistry reviews, 2017 - Springer
The discovery of the ellagitannin geraniin was made exactly 40 years ago. It is a secondary
metabolite found in plants and is categorised as a hydrolysable tannin under the huge family …
metabolite found in plants and is categorised as a hydrolysable tannin under the huge family …